HUMAN CHROMOSOME 2 FUSION FROM TWO CHIMPANZEE CHROMOSOMES

Authors
  • Katrina Cook

    Author

Abstract

Since the discovery of chromosomes in the early twentieth century, evolutionary scientists have proposed that a major event in ape-to-human evolution occurred less than 10 million years ago through the telomere-to-telomere fusion of two ancestral ape chromosomes to form human chromosome 2. Although the idea that living organisms acquired their anatomical structures through natural processes dates back to Aristotle, Charles Darwin articulated the central tenets of evolutionary theory. He proposed that natural selection directed changes within species and that anatomical similarities between humans and animals provided evidence that humans descended from a lower form of life, with the apes considered their closest living relatives because of their anatomical similarities to humans. Using chromosome-banding techniques, researchers compared human and ape chromosomes and observed that chimpanzee chromosomes 12 and 13 displayed banding patterns similar to those of human chromosome 2 when arranged end to end. These observations were presented as additional evidence that humans and chimpanzees share a common ancestor. However, subsequent genetic sequencing and comparative analyses of human and ape chromosomes have raised questions about this hypothesis. The genomic evidence examined in this paper challenges the claim that human chromosome 2 originated through the fusion of two ancestral ape chromosomes and permits alternative explanations of human origins to be considered.

Author Biography
  1. Katrina Cook

    Katrina Cook Nunley graduated from Gulf Coast Community College, then completed her studies at Toccoa Falls College in Toccoa, Georgia, earning a Bachelor of Arts degree in Christian Counseling Psychology and a teaching certificate in Bible, with a minor in Behavior Management. Shortly afterwards, she joined the United States Army as a Laboratory Specialist, earning an associate degree in laboratory technology at George Washington University. While serving in the Army, Katrina earned a Bachelor of Science degree in Nursing at Columbus State University in Columbus, Georgia. After 15 years of Army service, she retired as a Captain and earned a Doctorate Degree in Nursing Practice at Capella University. Katrina became a born-again Christian in 1988 and has been studying the Bible extensively since then. Katrina holds the worldview of young earth creation and believes the Bible to be the true historical record of all the universe. Her hobbies are reading, cooking, kayaking, fishing, and playing the flute. Katrina is a Assistant Professor in the School of Nursing at Columbus State University in Georgia.

    DNP, BSN, Assistant Professor, Columbus State University

References

Bach, J.-F. (2019). Genetic drift in mammals. Anais da Academia Brasileira de Ciências, 91(Suppl. 3), e20190339. https://doi.org/10.1590/0001-3765201920190339

Bergman, J., & Tomkins, J. P. (2011). The chromosome 2 fusion model of human evolution—Part 1: Re-evaluating the evidence. Journal of Creation, 25(2), 106–110.

Darwin, C. (2003). The origin of species: By means of natural selection, or the preservation of favoured races in the struggle for life (150th anniversary ed.). Signet Classics. (Original work published 1859)

Darwin, C. (2011). The descent of man, and selection in relation to sex. Pacific Publishing Studio. (Original work published 1871)

Dutta, A., Banerjee, B., Roy, S., & Halder, A. (2024). New discovery of a rare Robertsonian translocation (15;22)—A case report from India. Archives of Case Reports, 8(2), 42–47. https://doi.org/10.29328/journal.acr.1001092

Fan, Y., Linardopoulou, E., Friedman, C., Williams, E., & Trask, B. J. (2002). Genomic structure and evolution of the ancestral chromosome fusion site in 2q13–2q14.1 and paralogous regions on other human chromosomes. Genome Research, 12(11), 1651–1662. https://doi.org/10.1101/gr.337602

Fortin, F., Beaulieu Bergeron, M., Fetni, R., & Lemieux, N. (2009). Frequency of chromosome healing and interstitial telomeres in 40 cases of constitutional abnormalities. Cytogenetic and Genome Research, 125(3), 176–185. https://doi.org/10.1159/000230002

Hackett, J. A., Feldser, D. M., & Greider, C. W. (2001). Telomere dysfunction increases mutation rate and genomic instability. Cell, 106(3), 275–286. https://doi.org/10.1016/S0092-8674(01)00457-3

Hamerton, J. L., Jacobs, P. A., & Klinger, H. P. (Eds.). (1972). Paris Conference (1971): Standardization in human cytogenetics. Cytogenetics, 11, 313–362.

Hancock, Z. B., Lehmberg, E. S., & Bradburd, G. S. (2021). Neo-Darwinism still haunts evolutionary theory: A modern perspective on Charlesworth, Lande, and Slatkin (1982). Evolution, 75(6), 1244–1255. https://doi.org/10.1111/evo.14268

Ijdo, J. W., Baldini, A., Ward, D. C., Reeders, S. T., & Wells, R. A. (1991). Origin of human chromosome 2: An ancestral telomere–telomere fusion. Proceedings of the National Academy of Sciences of the United States of America, 88(20), 9051–9055. https://doi.org/10.1073/pnas.88.20.9051

Karimian, K., Groot, A., Huso, V., Kahidi, R., Tan, K.-T., Sholes, S., Keener, R., McDyer, J. F., Alder, J. K., Li, H., Rechtsteiner, A., & Greider, C. W. (2024). Human telomere length is

chromosome end-specific and conserved across individuals. Science, 384(6695), 533–539. https://doi.org/10.1126/science.ado0431

Liehr, T. (2014a). Introduction. In Benign & pathological chromosomal imbalances: Microscopic and submicroscopic copy number variations (CNVs) in genetics and counseling (pp. 1–11). Elsevier.

Liehr, T. (2014b). CG-CNVs: What is the norm? In Benign & pathological chromosomal imbalances: Microscopic and submicroscopic copy number variations (CNVs) in genetics and counseling (pp. 13–24). Elsevier. https://doi.org/10.1016/B978-0-12-404631-3.00002-7

Lopes, M., Louzada, S., Gama-Carvalho, M., & Chaves, R. (2021). Genomic tackling of human satellite DNA: Breaking barriers through time. International Journal of Molecular Sciences, 22(9), 4707. https://doi.org/10.3390/ijms22094707

Luskin, C. (2022). Chromosomal fusion and correcting mistakes: A retrospective on an old debate. Evolution News & Science Today. https://evolutionnews.org/2022/01/chromosomal-fusion-and-correcting-mistakes-a-retrospective- on-an-old-debate/

Martin, C. L., Wong, A., Gross, A., Chung, J., Fantes, J. A., & Ledbetter, D. H. (2002). The evolutionary origin of human subtelomeric homologies—or where the ends begin. The American Journal of Human Genetics, 70(4), 972–984. https://doi.org/10.1086/339768

Miller, D. A. (1977). Evolution of primate chromosomes: Man’s closest relative may be the gorilla, not the chimpanzee. Science, 198, 1116–1124.

Poszewiecka, B., Gogolewski, K., Stankiewicz, P., & Gambin, A. (2022). Revised time estimation of the ancestral human chromosome 2 fusion. BMC Genomics, 23, 616. https://doi.org/10.1186/s12864-022-08828-7

Sanford, J. C. (2014). Genetic entropy (4th ed.). FMS Publications.

Shao, Y., Lu, N., Wu, Z., Cai, C., Wang, S., Zhang, L.-L., Zhou, F., Xiao, S., Liu, L., Zeng, X., Zheng, H., Yang, C., Zhao, Z., Zhao, G., Zhou, J.-Q., Xue, X., & Qin, Z. (2018). Creating a functional single-chromosome yeast. Nature, 560(7718), 331–335. https://doi.org/10.1038/s41586-018-0382-x

Simpson, G. G. (1966). The biological nature of man: The answer to the ancient question “What is man?” must be based first on man’s biological character. Science, 152(3721), 472–478.

Song, J., Li, X., Sun, L., Xu, S., Liu, N., Yao, Y., Liu, Z., Wang, W., Rong, H., & Wang, B. (2016). A family with Robertsonian translocation: A potential mechanism of speciation in humans. Molecular Cytogenetics, 9, 48. https://doi.org/10.1186/s13039-016-0255-7

Stankiewicz, P. (2016). One pedigree we all may have come from—Did Adam and Eve have the chromosome 2 fusion? Molecular Cytogenetics, 9, 72. https://doi.org/10.1186/s13039-016-0283-3

Stroik, S., & Hendrickson, E. A. (2020). Telomere fusions and translocations: A bridge too far? Current Opinion in Genetics & Development, 60, 85–91. https://doi.org/10.1016/j.gde.2020.02.010

Suntsova, M. V., & Buzdin, A. A. (2020). Differences between human and chimpanzee genomes and their implications in gene expression, protein functions, and biochemical properties of the two species. BMC Genomics, 21(Suppl. 7), 535. https://doi.org/10.1186/s12864-020-06962-8

Tomkins, J. P. (2017). Debunking the debunkers: A response to criticism and obfuscation regarding refutation of the human chromosome 2 fusion. Answers Research Journal, 10, 45–54. https://www.answersingenesis.org/arj/v10/human_chromosome_2_fusion.pdf

Tomkins, J. P., & Bergman, J. (2011). The chromosome 2 fusion model of human evolution—Part 2: Re-analysis of the genomic data. Journal of Creation, 25(2), 111–117.

Ventura, M., Catacchio, C. R., Sajjadian, S., Vives, L., Sudmant, P. H., Marques-Bonet, T., Graves, T. A., Wilson, R. K., & Eichler, E. E. (2012). The evolution of African great ape subtelomeric heterochromatin and the fusion of human chromosome 2. Genome Research, 22(6), 1036–1049. https://doi.org/10.1101/gr.136556.111

Yoo, D., Rhie, A., Hebbar, P., Antonacci, F., Logsdon, G. A., Solar, S. J., Antipov, D., et al. (2025). Complete sequencing of ape genomes. Nature, 641(8062), 401–418. https://doi.org/10.1038/s41586-025-08816-3

Yunis, J. J., & Prakash, O. (1982). The origin of man: A chromosomal pictorial legacy. Science, 215(4539), 1525–1530. https://doi.org/10.1126/science.7063861

Yunis, J. J., Sawyer, J. R., & Dunham, K. (1980). The striking resemblance of high-resolution G-banded chromosomes of man and chimpanzee. Science, 208(4448), 1145–1148. https://doi.org/10.1126/science.7375922

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2026-07-29
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