HUMAN CHROMOSOME 2 FUSION FROM TWO CHIMPANZEE CHROMOSOMES
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Katrina Cook
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- Abstract
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Since the discovery of chromosomes in the early twentieth century, evolutionary scientists have proposed that a major event in ape-to-human evolution occurred less than 10 million years ago through the telomere-to-telomere fusion of two ancestral ape chromosomes to form human chromosome 2. Although the idea that living organisms acquired their anatomical structures through natural processes dates back to Aristotle, Charles Darwin articulated the central tenets of evolutionary theory. He proposed that natural selection directed changes within species and that anatomical similarities between humans and animals provided evidence that humans descended from a lower form of life, with the apes considered their closest living relatives because of their anatomical similarities to humans. Using chromosome-banding techniques, researchers compared human and ape chromosomes and observed that chimpanzee chromosomes 12 and 13 displayed banding patterns similar to those of human chromosome 2 when arranged end to end. These observations were presented as additional evidence that humans and chimpanzees share a common ancestor. However, subsequent genetic sequencing and comparative analyses of human and ape chromosomes have raised questions about this hypothesis. The genomic evidence examined in this paper challenges the claim that human chromosome 2 originated through the fusion of two ancestral ape chromosomes and permits alternative explanations of human origins to be considered.
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